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[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Mischley LK, Lau RC, Shankland EG, Wilbur TK, Padowski JM

[17] Does food intake influence efficacy Oral bioavailability approaches 100 %, but a light meal may delay Tmax by 30 minutes without altering total analgesic effect

Long term, it increases the risk of dependence and misuse

Indeed, several chemoprevention trials have reported that the reduction in biomarkers of cancer risk (e.g., aflatoxin-DNA adducts) following SFN intervention was predominantly observed in subjects with the GSTM1-null genotype ( This genotype-dependent efficacy is robustly supported by epidemiological and clinical evidence in colorectal cancer, particularly for individuals with combined GSTM1 and GSTT1 null genotypes

Key difference : Lipo-GSH penetrates via bulk transport (relies on liposome integrity)